667 A novel TGF-beta/Smad signaling inhibitor ameliorates bleomycin-induced skin fibrosis
نویسندگان
چکیده
منابع مشابه
A p38 MAPK inhibitor, FR-167653, ameliorates murine bleomycin-induced pulmonary fibrosis.
To elucidate the pathophysiology of pulmonary fibrosis, we investigated the involvement of p38 mitogen-activated protein kinase (MAPK), which is one of the major signal transduction pathways of proinflammatory cytokines, in a murine model of bleomycin-induced lung fibrosis. p38 MAPK and its substrate, activating transcription factor (ATF)-2, in bronchoalveolar lavage fluid cells were phosphoryl...
متن کاملMAP3K19 Is a Novel Regulator of TGF-β Signaling That Impacts Bleomycin-Induced Lung Injury and Pulmonary Fibrosis
Idiopathic pulmonary fibrosis (IPF) is a progressive, debilitating disease for which two medications, pirfenidone and nintedanib, have only recently been approved for treatment. The cytokine TGF-β has been shown to be a central mediator in the disease process. We investigated the role of a novel kinase, MAP3K19, upregulated in IPF tissue, in TGF-β-induced signal transduction and in bleomycin-in...
متن کاملEndostatin, an angiogenesis inhibitor, ameliorates bleomycin-induced pulmonary fibrosis in rats
BACKGROUND Recent evidence has demonstrated the role of angiogenesis in the pathogenesis of pulmonary fibrosis. Endostatin, a proteolytic fragment of collagen XVIII, is a potent inhibitor of angiogenesis. The aim of our study was to assess whether endostatin has beneficial effects on bleomycin (BLM)-induced pulmonary fibrosis in rats. METHODS The rats were randomly divided into five experimen...
متن کاملBlockade of TGF-β/Smad signaling by the small compound HPH-15 ameliorates experimental skin fibrosis
BACKGROUND Transforming growth factor-β (TGF-β)/Smad signaling is well known to play a critical role in the pathogenesis of systemic sclerosis (SSc). We previously developed an artificial molecule, the histidine-pyridine-histidine ligand derivative HPH-15, which may have an antifibrotic effect. The purpose of the present study was to clarify the effects of this drug in human skin fibroblasts an...
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A number of studies have previously provided evidence on the Anti-inflammatory properties of plant-derived compounds that can prevent lung injury. In this study, we attempted to analyze the therapeutic effects of PM 014 on inflammation and pulmonary fibrosis in COVID-19 as well as describing the treatment of one of the most challenging problems related to the coronavirus-19 (COVID-19). We belie...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2017
ISSN: 0022-202X
DOI: 10.1016/j.jid.2017.07.344